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Sleep Diagnosis and Therapy

Sleep Diagnosis and Therapy

Official Publication of the American Sleep and Breathing Academy

Vitamin D Supplement Labels may be Inaccurate

February 15, 2013 by admin

The amount of vitamin D in some supplements may be either much lower or much higher than what’s written on the label, according to a new analysis.

“Over-the-Counter and Compounded Vitamin D: Is Potency What We Expect?” is published in the JAMA Internal Medicine.

Read Abstract.

Researchers found that off-the-shelf pills from 12 different manufacturers had between 52 percent and 135 percent of their advertised vitamin D content.

And among vitamins mixed by compounding pharmacies, the variation in doses was even greater — from 23 percent to 146 percent of the labeled amount.

Vitamin D supplements can be bought for a few dollars per month.

Together with calcium, they have been tied to improved bone health. Other medical claims made for extra vitamin D — such as its ability to lower blood pressure or boost immunity — are more tenuous.

[ Related resource: The world epidemic of sleep disorders is linked to vitamin D deficiency ]

For the new study, Dr. Erin LeBlanc from the Kaiser Permanente Center for Health Researchin Portland, Ore., and her colleagues chemically analyzed pills from 15 vitamin D bottles purchased at local stores and two doses of compounded vitamins.

Supplement bottles were labeled as containing 1,000, 5,000 or 10,000 international units (IU) of vitamin D. Just one-fourth of the vitamins met the standard of all pills falling between 90 and 120 percent of the expected dose, based on a random selection of five pills per bottle.

Pills made by the one manufacturer that was verified by the U.S. Pharmacopeial Convention (USP) — a third-party tester — were all within six percent of the listed dose, LeBlanc and her colleagues found.

“Consumers buying those products can be more assured that what they’re getting in their pills is what’s labeled,” she said.

Compounded vitamin D pills were marked as 1,000 or 50,000 IU. Those high-dose vitamins can be prescribed by doctors and are mixed by pharmacies, unlike the store-bought brands. One-third of the pills met the slightly stricter dosing standards for compounded vitamins, according to the findings.

Compounding pharmacies have come under the microscope in recent months after a meningitis outbreak was tied to injectable steroids made by the New England Compounding Center in Framingham, Mass.

For most adults, the recommended daily allowance of vitamin D is 600 to 800 IU. However, people who are deficient in vitamin D are sometimes prescribed high doses to boost the amount in their blood.

The main concern with such wide variability, is that people with low vitamin D levels who rely on supplements may end up consistently getting less of the vitamin than is labeled in some cases.

Laws regulating supplements are often not strictly enforced, so companies can get away with spending less on manufacturing standards at the expense of quality and consistency. The best way for consumers to get supplements with the correct dose of ingredients is to purchase brands with a seal from USP or NSF International, another third-party verifier.

Source: Reuters

Filed Under: Blog

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SleepDT Sleep Diagnosis and Therapy is a clinical Journal for allied Sleep Professionals, Neurologists, Psychiatrists, Pulmonologists, Primary Care Physicians, and other medical specialists. We also advocate on behalf of patient care in the field of Sleep Medicine

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