• Skip to main content
  • Skip to primary sidebar
  • Skip to footer
  • Home
  • About Us
  • Blog
  • Subscribe to the Journal
  • Contact Us
Sleep Diagnosis and Therapy

Sleep Diagnosis and Therapy

Official Publication of the American Sleep and Breathing Academy

CPAP versus Oxygen in Obstructive Sleep Apnea

July 11, 2014 by admin

 

“In this four-site, randomized, parallel-group clinical trial, adult patients with significant cardiac risk factors or disease were screened for obstructive sleep apnea (OSA) using the Berlin questionnaire. Following home sleep testing, patients with significant OSA (AHI 15-50events/hour) were randomized to: healthy lifestyle and sleep education (HLSE) alone (control), CPAP with HLSE (Auto-CPAP), or supplemental oxygen with HLSE (2 L/min via nasal prongs). The primary outcome was 24-hour mean arterial pressure.

 

Of 318 patients who underwent randomization, 281 (88%) were evaluated for ambulatory blood pressure at both baseline and follow-up. Patients randomized to both the CPAP and supplemental oxygen groups had similar reductions in nocturnal hypoxemia. The adjusted 24-hour mean arterial pressure at 12 weeks was significantly lower in the CPAP group than in either the control group (−2.4mmHg; P=0.04) or the supplemental oxygen group (−2.8mmHg; P=0.02).

 

In patients with cardiovascular disease or multiple cardiovascular risk factors, the treatment of OSA with Auto-CPAP with HLSE resulted in a significant reduction in blood pressure compared to supplemental oxygen with HLSE or HLSEalone. Despite similar effects on nocturnal hypoxemia, the lack of a beneficial effect of supplemental oxygen suggests that factors such as frequent arousals, hypercapnia, and variation in intrathoracic pressure may play a role in hypertension resulting fromOSA. Future pragmatic studies are indicated mechanistic influences of supplemental oxygen (such as high vs. low loop gain or dose-response relationship), and prevention of long-term cardiovascular events.”

 

Gottlieb DJ, Punjabi NM, Mehra R, Patel SR, Quan SF, M.D., Babineau DC, Tracy RP, Rueschman M, Blumenthal RS, Eldrin F. Lewis EF, Bhatt DL, Redline S.
N Engl J Med 2014; 370:2276–2285  2014

Click Here for PubMed Abstract

Filed Under: Articles, Blog

Primary Sidebar

More to See

Snoring, American Sleep and Breathing Academy and the NY Times

August 23, 2022 By admin

Jazz Pharma Presents 17 New Posters for SLEEP 2022

June 6, 2022 By admin

Tags

apnea CPAP Health Home Sleep Home Sleep Testing insomnia narcolepsy obstructive sleep apnea Sleep sleep apnea sleep apnea symptoms sleep apnea syndrome sleep apnea treatment sleep appliances sleep buisness Sleep Business sleep center Sleep Centers sleep community sleep diagnosis sleep diagnostic sleep diagnostics sleep disease sleep disorder sleep disorder center sleep disordered breathing sleep disorders sleep heart health sleep industry sleeping Sleep Lab sleep labs sleep management sleep medicine sleep monitor sleep physicians sleep problems sleep studies sleep study sleep technologist sleep test sleep testing Technology therapy Treatment

Footer

About SleepDT

SleepDT Sleep Diagnosis and Therapy is a clinical Journal for allied Sleep Professionals, Neurologists, Psychiatrists, Pulmonologists, Primary Care Physicians, and other medical specialists. We also advocate on behalf of patient care in the field of Sleep Medicine

Recent

  • SUPPORT AND PROMOTE DENTAL SLEEP MEDICINE IN 2023!
  • Snoring, American Sleep and Breathing Academy and the NY Times
  • Jazz Pharma Presents 17 New Posters for SLEEP 2022
  • AJMC Hypes SLEEP 2022
  • Avadel Pharmaceuticals’ Stock Falls

NAVIGATION

  • Home
  • About Us
  • Blog
  • Subscribe to the Journal
  • Contact Us

Copyright © 2023 · Sleep Diagnosis and Therapy